Updated 07 August 2026 · HodieLabs Clinical Governance Lead · The HodieLabs Evidence-Based Clinical Library
Combined albumin and globulin; a broad indicator of liver and immune function. Total protein is measured by blood test as part of the Organ panel in the HodieLabs Health Blueprint.
Total protein = albumin + globulin; always fractionate to identify which component is driving abnormality. Dehydration can falsely elevate total protein. Ensure adequate hydration before testing.
Associated risks when out of range: Low total protein may indicate malnutrition, liver disease, or nephrotic syndrome. High total protein may suggest chronic inflammation, infection, or myeloma.
The HodieLabs Evidence-Based Clinical Library classifies Total protein as an strong evidence-tier biomarker. Its reference ranges come from a published authority standard rather than from observational optimisation targets. The standard used here is Aligned with largest Australian pathology laboratory reference interval; total protein 65–81 g/L. Consistent with RCPA guidance (60–80 g/L adjusted to match major Australian lab calibration). Where relevant clinical outcomes are noted on this page, they reflect the guideline literature referenced below.
The HodieLabs Evidence-Based Clinical Library interprets Total protein against published clinical authority standards, never arbitrary "optimal" ranges. Measured in g/L:
Recommended testing frequency: Annual, as part of a comprehensive panel. Single markers are always interpreted in context.
Total protein is measured in every Health Blueprint at our Melbourne Preventative Health & Longevity Clinic, interpreted by a doctor against the guideline-cited ranges above and tracked over time through your HodieLabs membership.
1. Aligned with largest Australian pathology laboratory reference interval; total protein 65–81 g/L. Consistent with RCPA guidance (60–80 g/L adjusted to match major Australian lab calibration).
This page is general information from the HodieLabs Evidence-Based Clinical Library, not medical advice. Speak with your GP about what testing and care is appropriate for you.
Combined albumin and globulin; a broad indicator of liver and immune function.
The HodieLabs Evidence-Based Clinical Library optimal range is 65–81 g/L, based on Aligned with largest Australian pathology laboratory reference interval; total protein 65–81 g/L. Consistent with RCPA guidance (60–80 g/L adjusted to match major Australian lab calibration).
Annual testing is recommended for most adults as part of a comprehensive preventative panel; more often if a result is being actively managed.
Evidence-supported levers include: investigate with albumin and globulin fractions to determine which component is abnormal, protein electrophoresis if globulin fraction is elevated. Interpretation and an action plan should always involve your doctor.
Total protein is measured in the HodieLabs Health Blueprint at our Melbourne Preventative Health and Longevity Clinic at 85 Spring Street, with doctor-led interpretation against evidence-based reference ranges.
Total protein and 50+ biomarkers, measured and doctor-interpreted at our Melbourne clinic.