Updated 07 August 2026 · HodieLabs Clinical Governance Lead · The HodieLabs Evidence-Based Clinical Library
The ratio of total cholesterol to HDL cholesterol. A widely used cardiovascular risk marker, lower ratios indicate a more favourable lipid profile. Total Cholesterol/HDL ratio is measured by blood test as part of the Cardiovascular panel in the HodieLabs Health Blueprint.
Out-of-range Total Cholesterol/HDL ratio is associated with clinically relevant conditions, which is why it is tracked as part of a comprehensive preventative panel.
Associated risks when out of range:.
The evidence base behind how the HodieLabs Evidence-Based Clinical Library interprets Total Cholesterol/HDL ratio, from randomised trials, prospective cohorts and genetic (Mendelian randomisation) studies. Full citations in the reference list below.
The HodieLabs Evidence-Based Clinical Library interprets Total Cholesterol/HDL ratio against published clinical authority standards, never arbitrary "optimal" ranges. Measured in ratio:
Recommended testing frequency: Annual, as part of a comprehensive panel. Single markers are always interpreted in context.
Total Cholesterol/HDL ratio is measured in every Health Blueprint at our Melbourne Preventative Health & Longevity Clinic, interpreted by a doctor against the guideline-cited ranges above and tracked over time through your HodieLabs membership.
1. Emerging Risk Factors Collaboration. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009;302:1993–2000.
This page is general information from the HodieLabs Evidence-Based Clinical Library, not medical advice. Speak with your GP about what testing and care is appropriate for you.
The ratio of total cholesterol to HDL cholesterol. A widely used cardiovascular risk marker, lower ratios indicate a more favourable lipid profile.
The HodieLabs Evidence-Based Clinical Library optimal range is <4.5 ratio, based on ESC-EAS 2019 dyslipidaemia guidelines and Framingham risk data; TC/HDL ratio <4.5 desirable for primary prevention. >5.0 associated with increased cardiovascular risk.
Annual testing is recommended for most adults as part of a comprehensive preventative panel; more often if a result is being actively managed.
Management depends on the underlying cause. Interpretation and an action plan should always involve your doctor.
Total Cholesterol/HDL ratio is measured in the HodieLabs Health Blueprint at our Melbourne Preventative Health and Longevity Clinic at 85 Spring Street, with doctor-led interpretation against evidence-based reference ranges.
Total Cholesterol/HDL ratio and 50+ biomarkers, measured and doctor-interpreted at our Melbourne clinic.