Updated 07 August 2026 · HodieLabs Clinical Governance Lead · The HodieLabs Evidence-Based Clinical Library
A marker of iron demand at the tissue level; elevated when iron stores are depleted. Soluble Transferrin Receptor (sTfR) is measured by blood test as part of the Organ panel in the HodieLabs Health Blueprint.
Complements ferritin; useful when inflammation confounds ferritin. Interpret using the reporting lab’s reference interval and clinical context; trend over time is often more informative than a single value.
Associated risks when out of range: Functional iron deficiency, Fatigue/performance limitation.
The HodieLabs Evidence-Based Clinical Library classifies Soluble Transferrin Receptor (sTfR) as an strong evidence-tier biomarker. Its reference ranges come from a published authority standard rather than from observational optimisation targets. The standard used here is Iron metabolism diagnostic consensus; sTfR 1.0–2.5 mg/L normal, elevated in functional iron deficiency independent of inflammation. Where relevant clinical outcomes are noted on this page, they reflect the guideline literature referenced below.
The HodieLabs Evidence-Based Clinical Library interprets Soluble Transferrin Receptor (sTfR) against published clinical authority standards, never arbitrary "optimal" ranges. Measured in mg/L (lab dependent):
Recommended testing frequency: Annual, as part of a comprehensive panel. Single markers are always interpreted in context.
Soluble Transferrin Receptor (sTfR) is measured in every Health Blueprint at our Melbourne Preventative Health & Longevity Clinic, interpreted by a doctor against the guideline-cited ranges above and tracked over time through your HodieLabs membership.
1. Iron metabolism diagnostic consensus; sTfR 1.0–2.5 mg/L normal, elevated in functional iron deficiency independent of inflammation.
This page is general information from the HodieLabs Evidence-Based Clinical Library, not medical advice. Speak with your GP about what testing and care is appropriate for you.
A marker of iron demand at the tissue level; elevated when iron stores are depleted.
The HodieLabs Evidence-Based Clinical Library optimal range is 1.0–2.5 mg/L (lab dependent), based on Iron metabolism diagnostic consensus; sTfR 1.0–2.5 mg/L normal, elevated in functional iron deficiency independent of inflammation.
Annual testing is recommended for most adults as part of a comprehensive preventative panel; more often if a result is being actively managed.
Evidence-supported levers include: stfr is elevated in true iron deficiency but not in anaemia of chronic disease. This is its key clinical utility, stfr/log(ferritin) index (ferritin index) is the most accurate single test for iron status in inflammatory states. Interpretation and an action plan should always involve your doctor.
Soluble Transferrin Receptor (sTfR) is measured in the HodieLabs Health Blueprint at our Melbourne Preventative Health and Longevity Clinic at 85 Spring Street, with doctor-led interpretation against evidence-based reference ranges.
Soluble Transferrin Receptor (sTfR) and 50+ biomarkers, measured and doctor-interpreted at our Melbourne clinic.