Updated 07 August 2026 · HodieLabs Clinical Governance Lead · The HodieLabs Evidence-Based Clinical Library
An essential electrolyte that regulates fluid balance and nerve function. Sodium is measured by blood test as part of the Organ panel in the HodieLabs Health Blueprint.
Interpret in clinical context and with medications (e.g. diuretics). Interpret using the reporting lab’s reference interval and clinical context; trend over time is often more informative than a single value.
Associated risks when out of range: Electrolyte imbalance, Cardiac/neuromuscular effects when abnormal (contextual).
The HodieLabs Evidence-Based Clinical Library classifies Sodium as an strong evidence-tier biomarker. Its reference ranges come from a published authority standard rather than from observational optimisation targets. The standard used here is RCPA Australian pathology reference intervals; serum sodium 135–145 mmol/L. <135 hyponatraemia, >145 hypernatraemia. Where relevant clinical outcomes are noted on this page, they reflect the guideline literature referenced below.
The HodieLabs Evidence-Based Clinical Library interprets Sodium against published clinical authority standards, never arbitrary "optimal" ranges. Measured in mmol/L:
Recommended testing frequency: Annual, as part of a comprehensive panel. Single markers are always interpreted in context.
Sodium is measured in every Health Blueprint at our Melbourne Preventative Health & Longevity Clinic, interpreted by a doctor against the guideline-cited ranges above and tracked over time through your HodieLabs membership.
1. RCPA Australian pathology reference intervals; serum sodium 135–145 mmol/L. <135 hyponatraemia, >145 hypernatraemia.
This page is general information from the HodieLabs Evidence-Based Clinical Library, not medical advice. Speak with your GP about what testing and care is appropriate for you.
An essential electrolyte that regulates fluid balance and nerve function.
The HodieLabs Evidence-Based Clinical Library optimal range is 135–145 mmol/L, based on RCPA Australian pathology reference intervals; serum sodium 135–145 mmol/L. <135 hyponatraemia, >145 hypernatraemia.
Annual testing is recommended for most adults as part of a comprehensive preventative panel; more often if a result is being actively managed.
Evidence-supported levers include: hydration/electrolyte management, clinical review if abnormal. Interpretation and an action plan should always involve your doctor.
Sodium is measured in the HodieLabs Health Blueprint at our Melbourne Preventative Health and Longevity Clinic at 85 Spring Street, with doctor-led interpretation against evidence-based reference ranges.
Sodium and 50+ biomarkers, measured and doctor-interpreted at our Melbourne clinic.