Ferritin index (sTfR/log ferritin): what your result means.

A calculated ratio that detects functional iron deficiency even when ferritin is normal. Ferritin index (sTfR/log ferritin) is measured by blood test as part of the Organ panel in the HodieLabs Health Blueprint.

Why Ferritin index (sTfR/log ferritin) matters

The ferritin index overcomes the limitation of ferritin being an acute phase reactant. Particularly useful in chronic disease states where ferritin is elevated by inflammation but iron stores are actually depleted.

Associated risks when out of range: Elevated index (>2.0) indicates iron-deficient erythropoiesis even when ferritin is normal or elevated. Most accurate single test for diagnosing iron deficiency in the presence of inflammation.

Evidence basis

The HodieLabs Evidence-Based Clinical Library classifies Ferritin index (sTfR/log ferritin) as an strong evidence-tier biomarker. Its reference ranges come from a published authority standard rather than from observational optimisation targets. The standard used here is Iron deficiency diagnostic consensus; sTfR/log(ferritin) index <1.0 adequate stores, >2.0 functional iron deficiency. Where relevant clinical outcomes are noted on this page, they reflect the guideline literature referenced below.

Evidence-based reference ranges

The HodieLabs Evidence-Based Clinical Library interprets Ferritin index (sTfR/log ferritin) against published clinical authority standards, never arbitrary "optimal" ranges. Measured in index:

Clinical interpretation

• The ferritin index overcomes the limitation of ferritin being an acute phase reactant.
• Particularly useful in chronic disease states where ferritin is elevated by inflammation but iron stores are actually depleted.
• Thomas plot integrates ferritin index with reticulocyte Hb to classify iron status into 4 quadrants.

What improves it: the evidence-based levers

• Calculated as sTfR / log(ferritin), derived from existing results
• Index >2.0: iron supplementation is indicated regardless of ferritin level

Recommended testing frequency: Annual, as part of a comprehensive panel. Single markers are always interpreted in context.

How Ferritin index (sTfR/log ferritin) testing works at HodieLabs

Ferritin index (sTfR/log ferritin) is measured in every Health Blueprint at our Melbourne Preventative Health & Longevity Clinic, interpreted by a doctor against the guideline-cited ranges above and tracked over time through your HodieLabs membership.

References

1. Iron deficiency diagnostic consensus; sTfR/log(ferritin) index <1.0 adequate stores, >2.0 functional iron deficiency.

This page is general information from the HodieLabs Evidence-Based Clinical Library, not medical advice. Speak with your GP about what testing and care is appropriate for you.