Updated 07 August 2026 · HodieLabs Clinical Governance Lead · The HodieLabs Evidence-Based Clinical Library
A non-specific inflammation marker that measures how quickly red blood cells settle. ESR is measured by blood test as part of the Inflammation panel in the HodieLabs Health Blueprint.
ESR rises with age and is naturally higher in females. Use age-adjusted reference ranges. ESR reflects changes over weeks (slow to rise, slow to fall) while CRP reflects hours to days.
Associated risks when out of range: Non-specific marker, elevated in infection, inflammation, autoimmune disease, and malignancy. Very high ESR (>100 mm/hr) suggests serious pathology requiring urgent investigation.
The HodieLabs Evidence-Based Clinical Library classifies ESR as an strong evidence-tier biomarker. Its reference ranges come from a published authority standard rather than from observational optimisation targets. The standard used here is IFCC/CLSI reference intervals with Westergren method; ESR upper limit approximated as Age/2 (male) or (Age+10)/2 (female). Age-adjusted tiers applied. ESR is nonspecific. hs-CRP (core_hscrp) is the primary inflammation optimisation marker. Where relevant clinical outcomes are noted on this page, they reflect the guideline literature referenced below.
The HodieLabs Evidence-Based Clinical Library interprets ESR against published clinical authority standards, never arbitrary "optimal" ranges. Measured in mm/hr:
Recommended testing frequency: Annual, as part of a comprehensive panel. Single markers are always interpreted in context.
ESR is measured in every Health Blueprint at our Melbourne Preventative Health & Longevity Clinic, interpreted by a doctor against the guideline-cited ranges above and tracked over time through your HodieLabs membership.
1. IFCC/CLSI reference intervals with Westergren method; ESR upper limit approximated as Age/2 (male) or (Age+10)/2 (female). Age-adjusted tiers applied. ESR is nonspecific. hs-CRP (core_hscrp) is the primary inflammation optimisation marker.
This page is general information from the HodieLabs Evidence-Based Clinical Library, not medical advice. Speak with your GP about what testing and care is appropriate for you.
A non-specific inflammation marker that measures how quickly red blood cells settle.
The HodieLabs Evidence-Based Clinical Library optimal range is Male <50: <15; Male ≥50: <20; Female <50: <20; Female ≥50: <30 mm/hr, based on IFCC/CLSI reference intervals with Westergren method; ESR upper limit approximated as Age/2 (male) or (Age+10)/2 (female). Age-adjusted tiers applied. ESR is nonspecific. hs-CRP (core_hscrp) is the primary inflammation optimisation marker.
Annual testing is recommended for most adults as part of a comprehensive preventative panel; more often if a result is being actively managed.
Evidence-supported levers include: esr is a screening test. Always follow up with specific investigations (crp, autoimmune panels, imaging), trending esr over time is more useful than a single measurement. Interpretation and an action plan should always involve your doctor.
ESR is measured in the HodieLabs Health Blueprint at our Melbourne Preventative Health and Longevity Clinic at 85 Spring Street, with doctor-led interpretation against evidence-based reference ranges.
ESR and 50+ biomarkers, measured and doctor-interpreted at our Melbourne clinic.