Updated 07 August 2026 · HodieLabs Clinical Governance Lead · The HodieLabs Evidence-Based Clinical Library
An adrenal hormone and precursor to sex hormones; declines with age. DHEA-S is measured by blood test as part of the Hormonal panel in the HodieLabs Health Blueprint.
DHEA-S is the most abundant circulating steroid and declines ~2% per year after age 25. Low DHEA-S correlates with frailty, reduced immune function, and accelerated ageing.
Associated risks when out of range: Aging axis proxy (low). Androgen excess (high, contextual).
The HodieLabs Evidence-Based Clinical Library classifies DHEA-S as an strong evidence-tier biomarker. Its reference ranges come from a published authority standard rather than from observational optimisation targets. The standard used here is Endocrine Society adrenal androgen guidelines; DHEA-S is age-dependent (peaks in 20s-30s, declines with age). Ranges shown are age-adjusted for adults 35-65. Where relevant clinical outcomes are noted on this page, they reflect the guideline literature referenced below.
The HodieLabs Evidence-Based Clinical Library interprets DHEA-S against published clinical authority standards, never arbitrary "optimal" ranges. Measured in µmol/L:
Recommended testing frequency: Annual, as part of a comprehensive panel. Single markers are always interpreted in context.
DHEA-S is measured in every Health Blueprint at our Melbourne Preventative Health & Longevity Clinic, interpreted by a doctor against the guideline-cited ranges above and tracked over time through your HodieLabs membership.
1. Endocrine Society adrenal androgen guidelines; DHEA-S is age-dependent (peaks in 20s-30s, declines with age). Ranges shown are age-adjusted for adults 35-65.
This page is general information from the HodieLabs Evidence-Based Clinical Library, not medical advice. Speak with your GP about what testing and care is appropriate for you.
An adrenal hormone and precursor to sex hormones; declines with age.
The HodieLabs Evidence-Based Clinical Library optimal range is Male: 3.0–10.0; Female: 1.5–7.0 µmol/L, based on Endocrine Society adrenal androgen guidelines; DHEA-S is age-dependent (peaks in 20s-30s, declines with age). Ranges shown are age-adjusted for adults 35-65.
Annual testing is recommended for most adults as part of a comprehensive preventative panel; more often if a result is being actively managed.
Evidence-supported levers include: sleep and recovery, resistance training, medical review if very low/high. Interpretation and an action plan should always involve your doctor.
DHEA-S is measured in the HodieLabs Health Blueprint at our Melbourne Preventative Health and Longevity Clinic at 85 Spring Street, with doctor-led interpretation against evidence-based reference ranges.
DHEA-S and 50+ biomarkers, measured and doctor-interpreted at our Melbourne clinic.