AST: what your result means.

A liver and muscle enzyme; elevated levels may indicate liver or tissue damage. AST is measured by blood test as part of the Organ panel in the HodieLabs Health Blueprint.

Why AST matters

Less liver-specific than ALT, also released from cardiac muscle, skeletal muscle, and red blood cells. AST/ALT ratio (De Ritis ratio) helps distinguish cause: >2 suggests alcohol, <1 suggests NAFLD.

Associated risks when out of range: Elevated in liver damage, muscle injury, cardiac events, and haemolysis, AST > ALT pattern (ratio >2) suggests alcoholic liver disease.

Evidence basis

The HodieLabs Evidence-Based Clinical Library classifies AST as an strong evidence-tier biomarker. Its reference ranges come from a published authority standard rather than from observational optimisation targets. The standard used here is Aligned with largest Australian pathology laboratory reference interval; AST 10–35 U/L. Consistent with RCPA guidance (10–40 U/L adjusted to match major Australian lab calibration). Where relevant clinical outcomes are noted on this page, they reflect the guideline literature referenced below.

Evidence-based reference ranges

The HodieLabs Evidence-Based Clinical Library interprets AST against published clinical authority standards, never arbitrary "optimal" ranges. Measured in U/L:

Clinical interpretation

• Less liver-specific than ALT, also released from cardiac muscle, skeletal muscle, and red blood cells.
• AST/ALT ratio (De Ritis ratio) helps distinguish cause: >2 suggests alcohol, <1 suggests NAFLD.
• Intense exercise can transiently elevate AST for 24–72 hours, time blood draws accordingly.

What improves it: the evidence-based levers

• Address alcohol/medication contributors
• Improve metabolic health

Recommended testing frequency: Annual, as part of a comprehensive panel. Single markers are always interpreted in context.

How AST testing works at HodieLabs

AST is measured in every Health Blueprint at our Melbourne Preventative Health & Longevity Clinic, interpreted by a doctor against the guideline-cited ranges above and tracked over time through your HodieLabs membership.

References

1. Aligned with largest Australian pathology laboratory reference interval; AST 10–35 U/L. Consistent with RCPA guidance (10–40 U/L adjusted to match major Australian lab calibration).

This page is general information from the HodieLabs Evidence-Based Clinical Library, not medical advice. Speak with your GP about what testing and care is appropriate for you.