The HodieLabs Evidence-Based Clinical Library is the public reference for how we interpret your biology, built on the same standards used by pathologists, cardiologists, endocrinologists and longevity researchers worldwide. Every biomarker range in a HodieLabs report is derived from a rigorous, science-backed evidence framework, never arbitrary numbers.
Every reference range and interpretation in the library is built in three layers:
Two principles are non-negotiable: we never narrow reference ranges to manufacture "optimisation" findings, normal values are never flagged as borderline, and every range cites its specific guideline source so you and your practitioner can verify our interpretation.
Evidence-based ranges, guideline sources and interpretation for the biomarkers that matter most. The complete HodieLabs panel. 105 biomarkers, every range cited to its clinical authority.
The main protein in HDL; reflects the body's cholesterol-clearing capacity.
View evidence & rangesMeasures atherogenic particles that drive plaque build-up in arteries.
View evidence & rangesRatio of atherogenic to protective particles; a key cardiovascular risk gauge.
View evidence & rangesA protein that slows triglyceride clearance; linked to cardiovascular risk.
View evidence & rangesA blood-clotting protein that also signals inflammation when elevated.
View evidence & rangesHigh-density lipoprotein cholesterol carries excess cholesterol from arteries back to the liver for clearance. Higher levels are generally cardioprotective, but HDL quality (efflux capacity) matters more than quantity alone. Longevity-focused interpretation considers HDL in context with triglycerides, ApoB, and insulin resistance markers.
View evidence & rangesAn amino acid associated with increased cardiovascular and cognitive risk when elevated (>15 µmol/L), but it is not a primary risk marker in ACC/AHA guidelines, and lowering levels has not consistently been shown to reduce cardiovascular events.
View evidence & rangesThe main cholesterol carrier linked to arterial plaque build-up.
View evidence & rangesA genetic cardiovascular risk factor that accelerates arterial plaque formation.
View evidence & rangesAn enzyme in arterial plaque that signals active vascular inflammation.
View evidence & rangesAll cholesterol except HDL; captures total atherogenic cholesterol burden.
View evidence & rangesA heart-stress marker released when the heart is under strain or overloaded.
View evidence & rangesLDL cholesterol that has been oxidised; directly drives arterial plaque formation.
View evidence & rangesLeftover cholesterol from triglyceride-rich particles; an emerging cardiovascular risk marker.
View evidence & rangesTotal cholesterol measures all cholesterol in the blood including LDL, HDL, and VLDL fractions. While historically used as a primary cardiovascular marker, it is now considered less informative than ApoB or LDL-C alone. Longevity-focused interpretation always contextualises TC with HDL, triglycerides, and ApoB.
View evidence & rangesThe ratio of total cholesterol to HDL cholesterol. A widely used cardiovascular risk marker, lower ratios indicate a more favourable lipid profile.
View evidence & rangesBlood fats strongly linked to insulin resistance and metabolic health.
View evidence & rangesA protein marker used primarily for ovarian cancer screening in women.
View evidence & rangesA prostate-specific protein used for prostate cancer screening in men.
View evidence & rangesThe primary stress hormone; morning levels reflect adrenal and HPA axis function.
View evidence & rangesAn adrenal hormone and precursor to sex hormones; declines with age.
View evidence & rangesThe primary female sex hormone; regulates menstrual cycle, bone, and heart health.
View evidence & rangesThe most active thyroid hormone; converts from T4 in tissues.
View evidence & rangesThe active thyroid hormone that regulates metabolism and energy.
View evidence & rangesThe biologically active fraction of testosterone not bound to SHBG or albumin. More clinically meaningful than total testosterone when SHBG is abnormal. Can be measured directly or calculated from total testosterone, SHBG, and albumin.
View evidence & rangesA growth-factor hormone reflecting growth hormone activity and tissue repair capacity.
View evidence & rangesA protein that binds sex hormones; affects how much testosterone and oestrogen is active.
View evidence & rangesThe primary male sex hormone; affects muscle, mood, energy, and metabolism.
View evidence & rangesThe pituitary hormone that controls thyroid function; first-line thyroid screen.
View evidence & rangesThe rarest white blood cell; involved in allergic and inflammatory responses.
View evidence & rangesStandard C-reactive protein; a general marker of infection or inflammation.
View evidence & rangesWhite blood cells involved in allergic responses and parasitic infections.
View evidence & rangesA non-specific inflammation marker that measures how quickly red blood cells settle.
View evidence & rangesA sensitive marker of low-grade inflammation linked to heart disease risk.
View evidence & rangesA key inflammatory cytokine involved in chronic disease and immune activation.
View evidence & rangesWhite blood cells central to immune defence; includes T-cells and B-cells.
View evidence & rangesWhite blood cells that become macrophages; involved in chronic inflammation.
View evidence & rangesRatio of neutrophils to lymphocytes; a marker of systemic inflammation.
View evidence & rangesThe most abundant white blood cell; first responders to bacterial infection.
View evidence & rangesA pro-inflammatory cytokine linked to chronic inflammation and autoimmune conditions.
View evidence & rangesRatio of liver enzymes AST to ALT; helps distinguish liver disease patterns.
View evidence & rangesA byproduct of insulin production; reflects how much insulin the pancreas makes.
View evidence & rangesBlood sugar level after fasting; a primary marker of glucose control.
View evidence & rangesFasting insulin level; an early marker of insulin resistance before glucose rises.
View evidence & rangesAverage blood sugar over the past 2–3 months; tracks long-term glucose control.
View evidence & rangesGlycated haemoglobin in IFCC standardised units (mmol/mol). Reflects average blood glucose control over the preceding 8–12 weeks.
View evidence & rangesA calculated index of insulin resistance from fasting glucose and insulin.
View evidence & rangesRatio of fasting insulin to glucose; another proxy for early insulin resistance.
View evidence & rangesA fat-tissue hormone that regulates appetite; elevated levels suggest leptin resistance.
View evidence & rangesRatio of triglycerides to HDL; a practical proxy for insulin resistance.
View evidence & rangesA waste product linked to gout, kidney stress, and metabolic syndrome when elevated.
View evidence & rangesThe biologically active form of B12; more accurate than total B12 for deficiency.
View evidence & rangesA trace mineral essential for iron metabolism, connective tissue, and nerve function.
View evidence & rangesRatio of omega-6 to omega-3 fats; lower ratios indicate better inflammatory balance.
View evidence & rangesA B-vitamin essential for DNA repair, red blood cell production, and methylation.
View evidence & rangesA mineral involved in 300+ enzyme reactions including energy, sleep, and muscle function.
View evidence & rangesA metabolite that rises with B12 deficiency; confirms functional B12 status.
View evidence & rangesPercentage of omega-3 fats in red blood cell membranes; reflects long-term intake.
View evidence & rangesA trace mineral essential for thyroid function and antioxidant defence.
View evidence & rangesA fat-soluble vitamin important for vision, immunity, and skin health.
View evidence & rangesA vitamin critical for nerve function, red blood cell production, and DNA synthesis.
View evidence & rangesA hormone-like vitamin essential for bone health, immunity, and inflammation control.
View evidence & rangesA fat-soluble antioxidant that protects cell membranes from oxidative damage.
View evidence & rangesA trace mineral essential for immune function, wound healing, and hormone production.
View evidence & rangesThe most abundant blood protein; reflects liver function and nutritional status.
View evidence & rangesRatio of albumin to globulin; helps assess liver function and immune balance.
View evidence & rangesAn enzyme from bone and liver; elevated levels may signal bone or liver conditions.
View evidence & rangesA liver enzyme that signals liver cell damage, especially from fatty liver disease.
View evidence & rangesA liver and muscle enzyme; elevated levels may indicate liver or tissue damage.
View evidence & rangesA buffer that maintains blood pH; reflects acid-base balance.
View evidence & rangesA breakdown product of red blood cells; reflects liver processing capacity.
View evidence & rangesEssential mineral for bones, muscle contraction, and nerve signalling.
View evidence & rangesAn electrolyte that helps maintain fluid balance and acid-base status.
View evidence & rangesA muscle enzyme; elevated levels indicate muscle damage or excessive exertion.
View evidence & rangesA muscle waste product filtered by the kidneys; used to estimate kidney function.
View evidence & rangesA kidney function marker more accurate than creatinine, especially in early decline.
View evidence & rangesEstimated kidney filtration rate; the primary measure of how well kidneys work.
View evidence & rangesFerritin is the primary iron storage protein and the most sensitive marker of total body iron stores. Low ferritin is the earliest indicator of iron depletion, while elevated ferritin can signal iron overload, inflammation, or liver disease. Longevity-focused interpretation aims for mid-range values.
View evidence & rangesA calculated ratio that detects functional iron deficiency even when ferritin is normal.
View evidence & rangesA liver enzyme sensitive to alcohol use, bile duct problems, and oxidative stress.
View evidence & rangesA group of immune and transport proteins; reflects immune and liver activity.
View evidence & rangesHaematocrit measures the percentage of blood volume occupied by red blood cells. It reflects both red cell production and plasma volume, making it sensitive to dehydration, altitude, and blood loss. Longevity-focused interpretation targets mid-range values.
View evidence & rangesThe oxygen-carrying protein in red blood cells; key indicator of anaemia.
View evidence & rangesAn enzyme released from damaged cells; a broad marker of tissue injury.
View evidence & rangesA pancreatic enzyme; elevated levels may indicate pancreatic inflammation.
View evidence & rangesMean corpuscular haemoglobin measures the average amount of haemoglobin per red blood cell. It parallels MCV and helps classify anaemia. Low MCH indicates iron deficiency or thalassaemia, while high MCH suggests B12 or folate deficiency.
View evidence & rangesThe average concentration of haemoglobin within each red blood cell. Helps classify anaemia types and detect red cell disorders such as hereditary spherocytosis.
View evidence & rangesAverage size of red blood cells; helps classify types of anaemia.
View evidence & rangesA mineral important for bone health, energy production, and cell function.
View evidence & rangesBlood cell fragments essential for clotting and wound repair.
View evidence & rangesAn essential electrolyte critical for heart rhythm and muscle function.
View evidence & rangesVariation in red blood cell size; elevated values may signal nutritional deficiency.
View evidence & rangesThe number of red blood cells; reflects oxygen-carrying capacity.
View evidence & rangesThe amount of iron circulating in the blood, available for immediate use.
View evidence & rangesAn essential electrolyte that regulates fluid balance and nerve function.
View evidence & rangesA marker of iron demand at the tissue level; elevated when iron stores are depleted.
View evidence & rangesA measure of urine concentration reflecting the kidney's ability to concentrate or dilute urine. Useful for assessing hydration status and interpreting other urine results.
View evidence & rangesCombined albumin and globulin; a broad indicator of liver and immune function.
View evidence & rangesTransferrin is the main iron transport protein in blood. It carries iron from the gut and storage sites to the bone marrow for red blood cell production. Elevated transferrin indicates iron deficiency (the body upregulates production to capture more iron), while low levels suggest iron overload or chronic disease.
View evidence & rangesPercentage of transferrin carrying iron; shows iron delivery to tissues.
View evidence & rangesA waste product from protein metabolism; reflects kidney function and hydration.
View evidence & rangesAlbumin detected in urine; signals early kidney microvascular damage.
View evidence & rangesAlbumin in urine relative to creatinine; an early marker of kidney damage.
View evidence & rangesCreatinine in urine; used to standardise other urine test results.
View evidence & rangesThe number of white blood cells; reflects immune system activity.
View evidence & rangesEvery HodieLabs Health Blueprint measures these biomarkers and interprets them against the Evidence-Based Clinical Library, with a doctor.